Ciprofloxacin HCL

Ciprofloxacin Base CAS 85721-33-1, Ciprofloxacin Lactate CAS 97867-33-9, 
Ciprofloxacin Hydrochloride or Hcl CAS 86483-48-9, Ciprofloxacin HCL
Product   Name: Ciprofloxacin Base API, Raw Material Ciprofloxacin Lactate API, Raw Material Ciprofloxacin Hydrochloride API, Raw Material
Synonyms: Cipfloxacine,


Ciprofloxacini Lactate Ciprofloxacin Hcl,

Ciprofloxacini hydrochloridum

CAS: 85721-33-1 97867-33-9 86483-48-9

or 86393-32-0

Appearance: White   crystalline powder White   powder or crystalline powder A   pale yellow, crystalline powder, soluble in water
Assay: 98.0%-102.0% 98.5%   Min 98%  ~ 102%
Formula: C17H18FN3O3 C20H22FN3O5 C17H18FN3O3,HCl,H2O
Package: 25Kg/Fiber Drum, Cardboard Drum, Paper Drum


Ciprofloxacin Lactate, Ciprofloxacin Hydrochloride are both slats of Ciprofloxacin. They are all broad-spectrum antimicrobial carboxyfluoroquinolines. They belong to fluoroquinolone class.  Ciprofloxacin Lactate, Ciprofloxacin Hydrochloride have bactericidal ability because they will inhibit enzymes topoisomerase II (DNA gyrase) and topoisomerase IV. There 2 enzymes needed in many bacterial DNA processes, like replication, transcription, repair, strand supercoiling repair, and recombination.

Ciprofloxacin Lactate, Ciprofloxacin Hcl are applied to treat many bacterial-caused infections such as  lung or respiratory tract infections, eye infection, bladder and kidney infections, reproductive tract infections, skin and soft tissue infections and bone and joint infections.

Till now, there is still no cross-resistance between ciprofloxacin and other classes of antimicrobials known to us. We should note that Ciprofloxacin Lactate, Ciprofloxacin Hydrochloride have 100 times higher affinity for bacterial DNA gyrase than for mammalian.

As a professional China Cipfloxacin Base,  Ciprofloxacin Lactate, Ciprofloxacin Hydrochloride Raw Material API supplier and Manufacturer, FENGCHEN GROUP CO., LTD has been supplying and exporting Cipfloxacin Base,  Ciprofloxacin Lactate, Ciprofloxacin Hydrochloride Raw Material API from China for almost 10 years.

Mechanism of Action:

The way of action of Cipfloxacin Base,  Ciprofloxacin Lactate, Ciprofloxacin Hydrochloride is different from that of other antimicrobial agents like beta-lactams, macrolides, tetracyclines, or aminoglycosides; That is to say, organisms which are resistant to these drugs are still ciprofloxacin. Ciprofloxacin Lactate, Ciprofloxacin Hydrochloride will still work to them.

Absorption of Ciprofloxacin Lactate, Ciprofloxacin Hydrochloride:

Ciprofloxacin will be  absorbed from the gastrointestinal tract after oral administration very quickly. The absolute bioavailability is approximately seventy percents with no substantial loss by first pass metabolism.

COA—Ciprofloxacin Base

Name of Product Ciprofloxacin base
Testing   Item Standard Result

Ciprofloxacin base

White crystalline powder
White   Crystalline Powder
Clarity of solution

Ciprofloxacin base

Meet the requirements Meets the requirements
Loss on drying ≤1.0% 0.2%
Residue on ignition ≤0.2% 0.12%
Heavy metals ≤0.002% ≤0.002%






Fluoroquinolonic acid Meet the requirements Meets the requirements
Ciprofloxacin ethylenediamine anlog ≤0.2% 0.05%
Any other individual impurity ≤0.2% 0.03%
Total impurities ≤0.5% 0.14%
Assay (on the anhydrous basis) 98.0%-102.0%

Ciprofloxacin Base


COA—Ciprofloxacin Lactate

Name   of Product Ciprofloxacin Lactate
Testing Item Standard Result

Ciprofloxacin Lactate

Almost   white or light yellow crystalline powder; Odorless and bitter, hygroscopicity Complies
Identification A Bismuth potassium Iodide solution   test: Solution shows brownish red. Complies
Identification B

Ciprofloxacin Lactate

UV: Absorption max at 277nm Complies
Identification C IR: Conforms to the reference spectrum Complies
Identification D

Ciprofloxacin Lactate

Lactate Test: Positive Complies
pH 4.5   ~ 5.5 4.9
Clarity of solution Clear Clear
Color   of solution Absorption   at 430nm ≤0.05 0.03
Fluoride ≥   4.2% 4.5%
Related   Substances Individual   Impurity ≤0.5%

Total   Impurities ≤1.0%

<   0.5%

<   1.0%

Loss   on drying (60 °C) ≤   6.5% 4.4%
Residual on Ignition ≤   0.1% 0.08%
Heavy   Metal ≤   20ppm <   20ppm
Assay   (Ciprofloxacin Lactate) ≥   98.5% on dried basis 98.9%

COA—Ciprofloxacin Hydrochloride (Ciprofloxacin Hcl)

Name   of Product Ciprofloxacin Hcl or Ciprofloxacin Hydrochloride
Testing Item Standard Result

Ciprofloxacin Hcl

Faintly   yellowish to light yellow crystals Complies
Identification   A IR   Spectrum of sample complies with the reference standard Complies
Identification   B

Ciprofloxacin Hcl

HPLC:   The retention time of the major peak of the sample solution corresponds to   the one of standard solution, as obtained in the assay Complies
Identification   C Show   reaction of chlorides. Complies
pH 3.0   ~ 4.5 3.7
Water 4.7%   ~ 6.7% 5.3%
Residue   on ignition ≤   0.1% 0.05%
Heavy   metals ≤   20ppm  Ciprofloxacin Hydrochloride <   20ppm
sulfate ≤   0.04% <   0.04%
Fluoroquinolonic   acid ≤   0.2% Complies
Ciprofloxacin   ethylenediamine ≤   0.2% 0.04%
Any   other individual impurity ≤   0.2% 0.05%
Total   impurities ≤   0.5% 0.18%
Ethanol ≤   4000ppm 426ppm
Isoamyl   Alcohol ≤   4000ppm Not   detected
Assay   (on the anhydrous basis) 98.0%   ~ 102.0%

Ciprofloxacin Hydrochloride (Ciprofloxacin Hcl)


Related products

Macrolides: Azithromycin, clarithromycin, roxithromycin
Quinolones: Ciprofloxacin hydrochloride, ciprofloxacin lactate, ciprofloxacin, ciprofloxacin mesylate, moxifloxacin
Special APIs: Azrendipine, fudosten, mitiglinide, desoxyfluridine, solifenacin, vildagliptin
Veterinary APIs: Ciprofloxacin hydrochloride, enrofloxacin, marbofloxacin, diclazuril, ciprofloxacin
Key pharmaceutical intermediates: Dihydrohomoerythromycin, erythromycin oxime, cyclopropanecarboxylic acid