Name: Clarithromycin
Molecular formula: C38H69NO
CAS NO.: 81103-11-9

Synonyms: Clarithromycine; Clathromycin, Clarithromycinum

Chemical name: 6-O-Methylerythromycin.

Forms: Clarithromycin Granular, Clarithromycin Granule; Clarithromycin Micronized Powder, Clarithromycin Micro Powder

Characteristics: White to off-white crystalline powder.

Assay: 94% Min

Formula: C38H69NO13

Structure Formula:

Fosfomycin Phenylethylamine Powder Raw Material, API BP, EP, USP structure.png

Density: 1.18 g/cm3

Melting Range: 217-220ºC

Package information: 25Kgs/Drum;  5KG/Drum, 10KG/Drum

KEY Words: Clarithromycin, Clarithromycine, Clarithromycinum Powder API, Raw Material

Storage: Store only in original container. Keep container tightly closed.

Quality standard: CP/  USP/  IP2014


Clarithromycin is a semisynthetic macrolide anti-biotic. It derives from erythromycin.

Clarithromycin will inhibit bacteria’s protein synthesis. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain elongation.

Clarithromycin is an antibiotic used to treat various bacterial infections. For example the infections of  includes strep throat, pneumonia, skin, H. pylori infection, and Lyme disease. Clarithromycin can be taken orally as a pill or liquid.

Developed in 1980. Clarithromycin is on the WHO’s List of Essential Medicines, it is the most important medications needed in a basic health system. Clarithromycin is available as a generic medication. Clarithromycin is made from erythromycin, and it have a chemical name 6-O-methylerythromycin.

Clarithromycin Powder API, Raw Material is a semi-synthetic macrolide antibiotic, which is chemically related to erythromycin and azithromycin. Clarithromycin is effective against a wide variety of bacteria, such as Haemophilus influenzae, mycobacterium avium, Streptococcus pneumoniae, etc. Like all macrolide antibiotics, Clarithromycin Powder API, Raw Material will interfere bacteria’s ability to make proteins, thus the growth will be stopped. Due to the differences in the way proteins are made in bacteria and humans, Clarithromycin will not interfere with production of proteins in humans. Clarithromycin Powder API, Raw Material derived from Streptomyces bacteria. It will inhibit protein synthesis by bacteria at the 50S ribosome. They are characterized by a macrocyclic ring (a large ring molecule with many functional groups bonded to it) and a large lactone ring in the molecular structure. Clarithromycin is usually used to produce medicines which is indicated for tract, skin, and genitourinary infections.

Clarithromycin Inhibits Myometrial Contractions in Isolated Human Myometrium Independent of Stimulus.


Clarithromycin Powder API, Raw Material will be classified as Antibacterial, Antibiotic, Anti-infective Agent, Gastrointestinal Agent, Macrolide.

As a professional China Clarithromycin Powder API, Raw Material supplier and Manufacturer in China, FENGCHEN GROUP CO., LTD has been supplying and exporting Clarithromycin Powder API, Raw Material from China in China for almost 10 years.

Side effects: 

There may be nausea, vomiting, headaches, and diarrhea. Severe allergic reactions are very rare. It may cause harm if taken during pregnancy.

The mechanism of action of Clarithromycin: 

Clarithromycin is an Inhibitor. It is in the macrolide class and works by stopping the making of protein by some bacteria.

 The chemical classification of Clarithromycin is Macrolides.


Clarithromycin is used to treatment of pharyngitis and tonsillitis caused by Streptococcus pyogenes, Acute otitis media, pneumonia and bronchitis caused by Streptococcus pneumoniae, Bronchitis and mycoplasma pneumonia caused by Haemophilus influenza and catarrh, skin and soft tissue infections caused by Staphylococcus and streptococcus.

-Clarithromycin can made into oral tablets or capsules. There are immediate-release form and an extended-release form.

-Clarithromycin may also be made into oral suspension.

Certificate of Analysis of Clarithromycin

Items Specifications Results


White to almost white crystalline powder white crystalline powder


Soluble in acetone;slightly soluble in

dehydrated alcohol, in methanol,

and in acctonitrile,and in phosphate butter at

PH values of 2 to5;

practically insoluble in water



IR:conforms to the spectrum of clarithromycin RS Conforms
Specific optical  rotation -94.–102.(anhydrous substance,1

0mg/ml methylene chloride)

Sulphated ash ≤ 0.2% <0.01%
Appearance of solution Clear or not more opalescent than reference

suspension II and not more intensely coloured than reference solutionY7

Crystallinity Meet the requirements Conforms
pH 8.0-10.0 8.7
Water ≤ 2.0% 0.35%
Related substances (1)any single impurity ≤ 1.0% 0.65%
(2)any impurities

greater than 0.4%

not more than 4 impurities 1
(3)total impurities ≤ 3.5% 2.0%
Heavy metals ≤ 0.002% 2.0%
Residul solvents Ethanol ≤ 5000ppm Not detected
Pyridine≤220ppm Not detected
Assay (on dried basis )


96.0% ~ 102.0%(anhydrous substance) 97.3%
Conclusion It complies with USP38 standard.

Other Names:

Biaxin; Clathromycin; Claritromicina; Claritromicina; 6-O-Methylerythromycin; 6-O-Methylerythromycin A; Clarithromycine; Clarithromycinum; (3R,4S,5S,6R,7R,9R,11S,12R,13S,14S)-6-([(2S,3R,4S,6R)-4-(dimethylamino)- 3-hydroxy-6- methyloxan -2-yl]oxy) -14-ethyl-12,13-dihydroxy-4-(((2R,4S,5S,6S)-5-hydroxy -4-methoxy- 4,6- dimethyloxan-2-yl)oxy)-7 -methoxy-3,5,7,9 ,11,13-hexamethyl -1-oxacyclotetradecane -2,10-dione

Related Products

Macrolides: Azithromycin, clarithromycin, roxithromycin
Quinolones: Ciprofloxacin hydrochloride, ciprofloxacin lactate, ciprofloxacin, ciprofloxacin mesylate, moxifloxacin
Special APIs: Azrendipine, fudosten, mitiglinide, desoxyfluridine, solifenacin, vildagliptin
Veterinary APIs: Ciprofloxacin hydrochloride, enrofloxacin, marbofloxacin, diclazuril, ciprofloxacin
Key pharmaceutical intermediates: Dihydrohomoerythromycin, erythromycin oxime, cyclopropanecarboxylic acid