Molecular formula: C38H69NO
CAS NO.: 81103-11-9
Synonyms: Clarithromycine; Clathromycin, Clarithromycinum
Chemical name: 6-O-Methylerythromycin.
Forms: Clarithromycin Granular, Clarithromycin Granule; Clarithromycin Micronized Powder, Clarithromycin Micro Powder
Characteristics: White to off-white crystalline powder.
Assay: 94% Min
Density: 1.18 g/cm3
Melting Range: 217-220ºC
Package information: 25Kgs/Drum; 5KG/Drum, 10KG/Drum
KEY Words: Clarithromycin, Clarithromycine, Clarithromycinum Powder API, Raw Material
Storage: Store only in original container. Keep container tightly closed.
Quality standard: CP/ USP/ IP2014
Clarithromycin is a semisynthetic macrolide anti-biotic. It derives from erythromycin.
Clarithromycin will inhibit bacteria’s protein synthesis. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain elongation.
Clarithromycin is an antibiotic used to treat various bacterial infections. For example the infections of includes strep throat, pneumonia, skin, H. pylori infection, and Lyme disease. Clarithromycin can be taken orally as a pill or liquid.
Developed in 1980. Clarithromycin is on the WHO’s List of Essential Medicines, it is the most important medications needed in a basic health system. Clarithromycin is available as a generic medication. Clarithromycin is made from erythromycin, and it have a chemical name 6-O-methylerythromycin.
Clarithromycin Powder API, Raw Material is a semi-synthetic macrolide antibiotic, which is chemically related to erythromycin and azithromycin. Clarithromycin is effective against a wide variety of bacteria, such as Haemophilus influenzae, mycobacterium avium, Streptococcus pneumoniae, etc. Like all macrolide antibiotics, Clarithromycin Powder API, Raw Material will interfere bacteria’s ability to make proteins, thus the growth will be stopped. Due to the differences in the way proteins are made in bacteria and humans, Clarithromycin will not interfere with production of proteins in humans. Clarithromycin Powder API, Raw Material derived from Streptomyces bacteria. It will inhibit protein synthesis by bacteria at the 50S ribosome. They are characterized by a macrocyclic ring (a large ring molecule with many functional groups bonded to it) and a large lactone ring in the molecular structure. Clarithromycin is usually used to produce medicines which is indicated for tract, skin, and genitourinary infections.
Clarithromycin Inhibits Myometrial Contractions in Isolated Human Myometrium Independent of Stimulus.
Clarithromycin Powder API, Raw Material will be classified as Antibacterial, Antibiotic, Anti-infective Agent, Gastrointestinal Agent, Macrolide.
As a professional China Clarithromycin Powder API, Raw Material supplier and Manufacturer in China, FENGCHEN GROUP CO., LTD has been supplying and exporting Clarithromycin Powder API, Raw Material from China in China for almost 10 years.
There may be nausea, vomiting, headaches, and diarrhea. Severe allergic reactions are very rare. It may cause harm if taken during pregnancy.
The mechanism of action of Clarithromycin:
Clarithromycin is an Inhibitor. It is in the macrolide class and works by stopping the making of protein by some bacteria.
The chemical classification of Clarithromycin is Macrolides.
Clarithromycin is used to treatment of pharyngitis and tonsillitis caused by Streptococcus pyogenes, Acute otitis media, pneumonia and bronchitis caused by Streptococcus pneumoniae, Bronchitis and mycoplasma pneumonia caused by Haemophilus influenza and catarrh, skin and soft tissue infections caused by Staphylococcus and streptococcus.
-Clarithromycin can made into oral tablets or capsules. There are immediate-release form and an extended-release form.
-Clarithromycin may also be made into oral suspension.
Certificate of Analysis of Clarithromycin
|White to almost white crystalline powder||white crystalline powder|
|Soluble in acetone;slightly soluble in
dehydrated alcohol, in methanol,
and in acctonitrile,and in phosphate butter at
PH values of 2 to5;
practically insoluble in water
|IR:conforms to the spectrum of clarithromycin RS||Conforms|
|Specific optical rotation||-94.–102.(anhydrous substance,1
0mg/ml methylene chloride)
|Sulphated ash||≤ 0.2%||<0.01%|
|Appearance of solution||Clear or not more opalescent than reference
suspension II and not more intensely coloured than reference solutionY7
|Crystallinity||Meet the requirements||Conforms|
|Related substances||(1)any single impurity||≤ 1.0%||0.65%|
greater than 0.4%
|not more than 4 impurities||1|
|(3)total impurities||≤ 3.5%||2.0%|
|Heavy metals||≤ 0.002%||2.0%|
|Residul solvents||Ethanol ≤ 5000ppm||Not detected|
|Assay (on dried basis )
|96.0% ~ 102.0%(anhydrous substance)||97.3%|
|Conclusion||It complies with USP38 standard.|
Biaxin; Clathromycin; Claritromicina; Claritromicina; 6-O-Methylerythromycin; 6-O-Methylerythromycin A; Clarithromycine; Clarithromycinum; (3R,4S,5S,6R,7R,9R,11S,12R,13S,14S)-6-([(2S,3R,4S,6R)-4-(dimethylamino)- 3-hydroxy-6- methyloxan -2-yl]oxy) -14-ethyl-12,13-dihydroxy-4-(((2R,4S,5S,6S)-5-hydroxy -4-methoxy- 4,6- dimethyloxan-2-yl)oxy)-7 -methoxy-3,5,7,9 ,11,13-hexamethyl -1-oxacyclotetradecane -2,10-dione
Macrolides: Azithromycin, clarithromycin, roxithromycin
Quinolones: Ciprofloxacin hydrochloride, ciprofloxacin lactate, ciprofloxacin, ciprofloxacin mesylate, moxifloxacin
Special APIs: Azrendipine, fudosten, mitiglinide, desoxyfluridine, solifenacin, vildagliptin
Veterinary APIs: Ciprofloxacin hydrochloride, enrofloxacin, marbofloxacin, diclazuril, ciprofloxacin
Key pharmaceutical intermediates: Dihydrohomoerythromycin, erythromycin oxime, cyclopropanecarboxylic acid