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Aquinity² P10 deionised water system, MembraPure

Aquinity² P10 deionised water system, MembraPure, Germany

Aquinity² P versions produce deionised water (< 1 µS/cm/ > 1 MOhm x cm) by reverse osmosis and conditioning module in to the external reservoir (35 liter or 70 liter). The water can be tapped directly (e.g. for glassware cleaning by hand) or connecting the tank to a laboratory dishwasher. Out of the storage tank the ultrapure water is produced and then can be tapped with a flexible dispenser. The Aquinity² water purification system is available in different configurations (Reagent, Analytical & LifeScience) to meet the specific requirements of ultra pure water for different applications.  Analytical is a version with UV lamp for low TOC value. Life Science version comes with UV lamp and Ultrafiltration Module for low TOC and low endotoxin values. An optional integrated TOC sensor allows the user to monitor the TOC content permanentely online. Besides that the Aquinity² can be configured as bench top or bench-integrated system with external panel and wall mounted (with inclined display). The tank can be installed at the side or above the system or even underneath the bench. Upon request the tanks can be connected in series to reach a bigger volume of reservoir.

Technical Specifications of produced water:

• Resistivity/Conductivity: > 1 MOhm x cm | < 1 µS/cm; Type II
• 2 MOhm x cm | 0.055 µS/cm; Type I
• production rate: 10 L/h, optionally 20 L/h

Total Organic Carbon (TOC):

< 10 ppb (Reagent)

< 5 ppb (Life Science)

< 3 ppb (Analytical)

Advantages of the new systems

• Compact housing
  • Big touchscreen
  • Remote service module
• Menus and wizards easy to use and mistake avoiding
  • New fixed and flexible dispenser
  • Easy access for cartridge exchange

OPTIONS

Bench integrated configuration (BI version)

To save valuable benchtop space the system can be ordered as BI configuration. The system will be installed underneath the work bench and only the display and dispenser are mounted on the wall.

Wall mounted configuration

To save valuable benchtop space the system can be ordered as wall mounted configuration. the whole system can be mounted on the wall with inclined display.

TOC-Monitoring (TI version)

The TOC monitoring during production and intermittent measurements during non-use periods allows to check the organic content in water continuously. The TOC value is measured between 1 and 999 ppb and can be shown in the display to monitor organic impurities.

volumetric dispensing

Our dispenser allows the volumetric controlled dispensing of water with an increment of 0.1 L and a tap volume from 0.1 to 99 L. The system prevents overflow of containers and allows to dispense water without supervising.

Aquinity² ultra pure water, MembraPure

Aquinity² ultra pure water, MembraPure, Germany

Aquinity² models produce ultra pure water directly from tap water. The Aquinity² P10 ultrapure water system is equipped with a reverse osmosis (RO) module to produce deionised water directly into an integrated 10l tank.  In the next step Type I grade water is produced with a polisher cartridge. The Aquinity² water purification system is available in different configurations (Reagent & Analytical) to meet the specific requirements of ultra pure water for different applications.  Analytical is a version with UV lamp for low TOC value. Life Science grade water with low endotoxin can be generated with a special final filter. An optional integrated TOC sensor allows the user to monitor the TOC content permanentely online. Besides that the Aquinity² can be configure as bench top or bench-integrated system, where the control panel will mounted on the wall.

Technical Specifications of produced water:

• Resistivity/Conductivity:18.2 MOhm x cm | 0.055 µS/cm; Type I
• production rate: 8 L/h
• Total Organic Carbon (TOC): < 10 ppb (Reagent)< 3 ppb (Analytical)

Advantages of the new systems

• Compact housing
  • Big touchscreen
  • Remote service module
• Menus and wizards easy to use and mistake avoiding
  • New fixed and flexible dispenser
  • Easy access for cartridge exchange

OPTIONS

Bench integrated configuration (BI version)

To save valuable benchtop space the system can be ordered as BI configuration. The system will be installed underneath the work bench and only the display and dispenser are mounted on the wall.

Wall mounted configuration

To save valuable benchtop space the system can be ordered as wall mounted configuration. the whole system can be mounted on the wall with inclined display.

TOC-Monitoring (TI version)

The TOC monitoring during production and intermittent measurements during non-use periods allows to check the organic content in water continuously. The TOC value is measured between 1 and 999 ppb and can be shown in the display to monitor organic impurities.

volumetric dispensing

Our dispenser allows the volumetric controlled dispensing of water with an increment of 0.1 L and a tap volume from 0.1 to 99 L. The system prevents overflow of containers and allows to dispense water without supervising.

Astacus² system, MembraPure

Astacus² ultra pure water, MembraPure, Germany

The Astacus² system is designed for the production of ultra pure water out of permeate from a reverse osmosis or deionised water. The Astacus² water purification system is available in different configurations (Reagent, Analytical & LifeScience) to meet the specific requirements of ultra pure water for different applications.  Analytical is a version with UV lamp for low TOC value. Life Science version comes with UV lamp and Ultrafiltration Module for low TOC and low endotoxin values. An optionally integrated TOC sensor allows the user to monitor the TOC content permanentely online. Besides that the Astacus² can be configured as bench top or bench-integrated system with external panel and wall mounted (with inclined display). The μS-control checks the conductivity of feed water to protect the cartridges against inappropriate feed water. If conductivity is too high the water flow will be rejected.

Technical Specifications of produced water:

Resistivity/Conductivity:18.2 MOhm x cm | 0.055 µS/cm; Type I

Production rate: max. 2 L/min

Total Organic Carbon (TOC):

< 10 ppb (Reagent)

< 5 ppb (Life Science)

< 3 ppb (Analytical)

Advantages of the new systems

• Compact housing
• Big touchscreen
• Remote service module
• Menus and wizards easy to use and mistake avoiding
• New fixed and flexible dispenser
• Easy access for cartridge exchange

OPTIONS

Bench integrated configuration (BI version)

To save valuable benchtop space the system can be ordered as BI configuration. The system will be installed underneath the work bench and only the display and dispenser are mounted on the wall.

Wall mounted configuration

To save valuable benchtop space the system can be ordered as wall mounted configuration. the whole system can be mounted on the wall with inclined display.

TOC-Monitoring (TI version)

The TOC monitoring during production and intermittent measurements during non-use periods allows to check the organic content in water continuously. The TOC value is measured between 1 and 999 ppb and can be shown in the display to monitor organic impurities.

volumetric dispensing

Our dispenser allows the volumetric controlled dispensing of water with an increment of 0.1 L and a tap volume from 0.1 to 99 L. The system prevents overflow of containers and allows to dispense water without supervising.

µS-control

The μS-control checks the conductivity of feed water to protect the cartridges against feed water of poor quality. If conductivity of the feed water is too high this water will be rejected and cannot influence the quality of the ultrapure water or harm the cartridge.

uniTOC, MembraPure

uniTOC, MembraPure, Germany

The uniTOC device uses the full oxidation by UV. The oxidation process can be enhanced with additional dosage of reagent (persulfate). By using the NDIR detector the uniTOC gives precise results in applications of ground water to ultrapure water. The NDIR detector is absolutely selective to carbon dioxide and therefore independent from conductivity and sample temperature. Measuring times are short and the continuous self-cleaning of the reactor avoids any cross-contamination. Since the quality of the stripped gas can be low, the use of pressurised air in combination with our air filters saves money and is optionally available.

Technical Specifications:

method & detection: UV oxidation (full) & NDIR

sample volume flow: 20 mL (low range), 5 mL loop (high range)

Total Organic Carbon (TOC) range: 2 to 5000 ppb (low range), 15 ppb to 20 ppm (high range)

related norms: USP <643>, EP 2.2.44, DIN 32645, 21 CFR part 11, IP 45

uniTOC advantages

• NDIR detector / TOC is detected directly over CO2 and not via a 3rd parameter (conductivity). Therefore no limit to conductivity.
  • available for two ranges of TOC
  • 9 months UV lamp life guarantee / 50% longer life time range than usual
• 2 sample inlets / 2 points of the loop can be measured ,so double efficiency
  • Remote service / Instrument can be connected to internet to get service diagnosis

Calibration & System Suitability Test (SST)

Calibration and SST of the uniTOC is easy and can be done by the user. Online operation is interrupted briefly for the system checks to be performed. The operator simply has to connect the inlet with the calibration standard solutions and the diluting water sample. The software enables the user to perform calibration and SST independently and the programmable sequence ensures the automatic procedure and data evaluation of the test. The verification of the TOC results according to the requirements of USP and Ph.Eur is realised by the periodic performance of system suitability tests.

OPTIONS

pressure regulator for medium

If the feed pressure is higher than 1.5 bar a pressure transducer is required,

offline version

An offline configuration is available for the uniTOC

air filtration unit

to use compressed air instead of oxygen or nitrogen

heat exchanger

keeps the temperature below 50 °C degrees

miniTOC, MembraPure

miniTOC, MembraPure, Germany

The miniTOC instrument uses the classical flow-through concept for online or offline TOC monitoring of pure and ultra pure water.The efficient UV oxidation of organic compounds by the “direct surface” principle in combination with conductivity detection guarantees the fast monitoring of values.

Technical Specifications:

Method & detection: UV-Oxidation & conductivity

Sample volume flow: ca. 14 mL/min

Total Organic Carbon (TOC)-Range: 0.5 to 1000 ppb

Related norms: USP <643>, EP 2.2.44, DIN EN 1484

miniTOC advantages

• Low sample volume / lower cost and waste
• 9 months UV lamp life guarantee / 50 % longer life time range than usual
• Continuous measurement (every 2 seconds) / fast reaction
• offline measurement / grab samples can be measured
• up to 3 sample inlets / very efficient
• remote service / Instrument can be connected to internet to get service diagnosis)

Calibration & System Suitability Test (SST)

Calibration and SST of the miniTOC is easy and can be done by the user. Online operation is interrupted briefly for the system checks to be performed. The operator simply has to connect the inlet with the calibration standard solutions and the diluting water. The software enables the user to perform calibration and SST independently and the programmable sequence ensures the automatic procedure and data evaluation of the test. The verification of the TOC results according to the requirements of USP and Ph.Eur is realised by the periodic performance of system suitability tests.

OPTIONS

intervall mode:

The miniTOC can be ordered as configuration with 4 inputs (miniTOC pro). With an additional software upgrade option the user can measure up to 3 loops sequentially.

Offline Version & autosampler

An offline configuration is available for the miniTOC. By using the offline mode of the miniTOC pro the system is also upgradable with an autosampler with 15 positions for 100 mL vials.

check of sample flow

Initiates alarm in case of inlet flow is zero

heat exchanger

If the medium temperature is higher than 50 °C a heat exchanger is required.

pressure regulator

If the medium pressure is higher than 1 bar a pressure transducer is required.

21 CFR part 11 Software

Software with 21 CFR part11 conformity for pharma applications.

IP 54

The housing protects the miniTOC from dust deposits and water jets.

conductivity range

extended conductivity of sample up to 10 µS/cm

ION analyser, MembraPure

ION Analyser, MembraPure

The ion chromatograph is offered in two different detection variants with regard to different applications. As standard, this is detection by conductivity (IONUS) and for special applications this detector is replaced by post-column derivatization with photometers of different wavelengths in the UV/VIS range (IONUS Post Column Derivatization) in analogy to our amino acid analyzer ARACUS.

By default, we equip our chromatographs almost exclusively with columns from Hamilton in Stainless Steel or PEEK. Columns from other manufacturers are available for certain special applications and on request. We also develop individual applications for you, which are specially tailored to your wishes and your separation problem.

IONUS

This IONUS is suitable for the analysis of anions and cations in research, development and everyday routine. The sample solutions are mostly water-based and may contain water-miscible organic solvents. A classic example is the analysis of (drinking) water according to EPA 300 Part A and B.

The advantage of IONUS is the compatibility with IC columns of all manufacturers and is compatible with all common eluents of anion and cation chromatography. In order to measure smaller concentration ranges in anion analysis, the instrument can be equipped with suppressor technology.

When applying without suppressor technique, it can happen that in the chromatogram there are negative as well as positive peaks for the individual substances or that the peak areas are very small due to very small conductivity differences. In this case the external UV/VIS detector can provide a remedy by using indirect UV detection for light-absorbing eluents. Another possibility is to use non-absorbent eluents for light-absorbing sample substances.

IONUS Post Column Derivatization

This generally more complex detection technique is used if the detection by means of conductivity provides only very small peaks, so that the sensitivity is quite low or this optical detection is much more sensitive. This can reduce the detection limit by orders of magnitude, as for example with bromate to less than 1 ppb.

This IONUS Post Column Derivatization (PCD) does not have a built-in conductivity detector. Instead, it has a reactor for derivatization followed by a single wavelength photometer. Different wavelengths are required for these special applications and used colour reactions. These single wavelength photometers are very sensitive compared to a variable UV/VIS detector, and it can be easily changed by the user. The choice of wavelength depends on the selected colour reaction, such as for the two bromate determinations according to EPA 317 or 326 with 440 nm or 355 nm.

This IONUS PCD also offers the advantage that it can be used with IC columns of all manufacturers and is compatible with all common eluents of anion and cation chromatography.

Technical Specifications:

Method: ion exchange chromatpgraphy with in built conductivity detector, optional with UV detection Or post column derivatization for bromate or transition metals analysis with UV/VIS Detector

Conductivity detection: noise: 0.02 µS, 1 s | linearity: < 1 s | range: 0 – 10 mS/cm

Reproducibility: 0.1 % RSD at 100 µL/min

IONUS features

Anion analysis

Applications for F–,Cl–, ClO₂-, ClO₃-, Br–, BrO₃^–, NO₂^–, NO₃^–, PO₄^3-, SO₄^2-, I^– silicate in water with and without chemical suppressor technique (according to EPA 300.0 & EPA 300.1) are available.

Cation analysis

Different methods have been developed for analysis of cations like NH₄⁺, Li⁺, Na⁺, K⁺, Ca²⁺, Mg²⁺, Sr²⁺, Ba²⁺.

Derivatization

Modified for post-column derivatisation, very low detection levels for bromate (according EPA 317.0 or EPA 326) or transition metals (VIS detection) are realised.

Detection

Anions and cations can be measured subsequently with conductivity detector. If requested the IONUS can be equipped with UV/VIS detector for indirect detection.

Consumables & spare parts

The IONUS is compatible with the common eluents and columns (max. operating pressure 120 bar) for anion and cation exchange chromatography. The customer is not limited to one brand.

Profile:

Columns: the IONUS works with the common columns (stainless steel/PEEK) with max. operating pressure of 120 bar.

Eluents: because IONUS works with the common eluents based on carbonate/bicarbonate buffers, nitric acid, sulufirc acid, the customer is not bound to a specific product.

OPTIONS

Manual injection port

easy manual injection with Rheodyne valve with a standard volume of 20 µL (other loops up on request)

Anion suppressor technique

based on chemical process regeneration of suppressors with acid.

Separation of transition metals

by using carboxylic acids (oxalic, tartaric, citric acid) as eluents and the complexing agent (PAR) 4-(2-Pyridylazo)resorcin the concentration levels of transition metals can be determined.

Indirect UV detection

the IONUS can be equipped with an additional UV/VIS detector.

Post column derivatization to determine bromate

The bromate analyzer is a dedicated configuration for the analysis of bromate in water based samples with a detection limit of 1 ppb. Depending on what is requested, the derivatization can be performed with Dianisidine (EPA 317) or Triiodide (EPA 326) together with a UV/VIS detector.

Amino acid analyser, ARACUS, MembraPure

Amino Acid Analyser ARACUS, MembraPure, Germany

The ARACUS is a dedicated amino acid analyser for high end analysis of amino acids in research, food quality control (own patent 10 2016 010 887), beverages and feedstuff and in the clinical laboratory. It combines innovative technologies with the classic routine analysis of amino acids by post-column derivatization with ninhydrin and the detection at 440 nm and 570 nm using maintenance-free LED photometers. The setup of the instrument allows the continuous analysis of 96 samples (2 x 48 vials) in a cooled autosampler. The pump allows the simultaneous operation of two fluid lines (eluent line and reactive line), which guarantees a constant mixing. Eluents and reagent solution are selectively chosen through valves and are ideally mixed to each other. The addition of ninhydrin provides a quantitative analysis statement. A washing routine of the injection valve and syringe pump avoids cross contaminations.The level of the individual reagents can be monitored during the runs and warns the user if the quantity is no longer sufficient.

The data acquisition and analysis software aminoPeak or Clarity records two analogue channels simultaneously (570 nm, 440 nm). Chromatograms are shown online. Internal databases allow fast peak identification. Quantitative calculations are performed with internal or external standards, dilution and/or multiplication factors. Several analysis runs can be compared using compiler programmes. The results of each analysis are documented in an individual report.

Ready-to-use kits

The concept behind the ready-to-use eluent and reagent kits allows the reproducible analysis of amino acid samples. Each kit is produced under standardised procedures, tested and certified before shipping. Depending on the application, the eluent and reagent kit contains the necessary amount for about 500 runs. Kits and columns are optiomally matched to each other.

Technical Specifications:

Method: post colum derivatization with ninhydrine

Spectroscopic detection: LED photometers: 440 nm + 570 nm

Detection limit: < 2 nmol/mL

Reproducibility of retention time: < 0.3 % RSD

Reproducibility of area: ca. 1 % RSD

ARACUS advantages

• detectors with maintenance-free LED technology (440 & 570 nm)/ no UV/VIS lamp degeneration and lamp exchange
• chloride-free and citrate-free buffer system / less aggressive to the components of the liquid handling tubes, fittings and connection
• small eluent consumption / about 200 µL/min in analysis mode
• high sensitivity of amino acids / choice of two sensitivity detector levels
• level sensors for eluents / warn the user if needed fluidic volume is too low for planned analysis
• easy access to all components of the entire system

OPTIONS

ARACUS advanced

2 pump system allows to operate with a lower noise level and are required for OPA post column derivatization method.

OPA method

Sensitive fluorescent detection reagent for amines with o-phtalaldehyde (OPA). Configuration ARACUS advanced is needed.

level control

Active control of fluid volume by weight cell of each bottle

IQ and OQ documents

prepared documents for the IQ and OQ procedure. Validation support can also be requested additionally.

inert gas

It supplies the main unit and eluent box with a protective gas atmosphere by reducing the presence of atmospheric oxygen to enhance the signal to noise ratio.

software 21 CFR part 11 compliance

As an option, Clarity can be used if 21 CFR Part 11 conformity is required for manual and automatoc peak integration with integreated IQ/OQ procedure for software.

InVitro diagnostic Kit according to DIN ISO 13485

IVD kits for the qualitative and quantitative determination of amino acids in physiological fluids, for in vitro diagnostic use with ARACUS amino acid analyser.

APPLICATIONS

Determination of free/ physiological amino acids in blood plasma, serum, salvia and urine newborn screening

– Argininemia (ARG)
– Arginosuccinic aciduria (ASA)
– Citrullinemia (CIT)
– Homocystinuria (HCY)
– Maple syrup urine disease (MSUD)
– Phenylketonuria (PKU)
– Ornithine transcarbamylase deficiency (OTC)
– Tyrosinemia (TYR)

Determination of hydrolysed amino acids in food, beverages and feedstuff

Food:

– meat
– cheese

Beverages:

– beer
– milk
– juice
– tea
– wine

Feedstuff:

– fish feed

Determination of biogenic amine for the investigation of metabolic processes plant

– growth factor: Tryptamine

Animal & human

– neurotransmitter: Histamine, Serotonin, Dopamine etc.